Thoughts

Quantum Computing
No need
Only need a good enough computer for autopilot and controls
Fly-by-wire
Optical Computing
Nope
Aneutronic Fusion - Uber high temperatures, maybe feasible in the distant future, but probably not able to do right now with tokamaks or compact fusion
How do we direct a few billion degree thrust?
How do we direct a few million degree thrust? 

How does compact fusion create thrust? Shape and consistency? 
compact fusion lawson's criterion
Magnetic nozzle for greater thrust control and not burn our nozzle
Muon generator, not important

Self-repairing hull
How do we get it to work in space
Kevlar shielding, use a self-repairing hull for multiple hits
Scab
AI monitors, inside and outside security
Reacting as it's happening, simulations
Another human being ship
Adaptive
Self-healing
Self-aware because of all the sensors
Nanorobotics
Robots that spray catalyst
Robot bay
Mothership "Orca"
"Remoras" - magnetic with spray thingy and other repair stuff
The heart, the brain, the legs